What to Expect with Stage 3 Lymphoma in Dogs

When my dog Colt was diagnosed with Stage 3 lymphoma, our world turned upside down.

He was more than just a pet—he was my shadow, my hiking buddy, the one who instinctively knew when I needed a nudge of love. Navigating his diagnosis was one of the hardest things I’ve ever done, and I hope that by sharing our story, it helps other pet parents facing the same fight.

What Is Stage 3 Lymphoma in Dogs?

Lymphoma is one of the most common cancers in dogs, affecting the lymphatic system. In Stage 3, the cancer is considered advanced: it has spread to lymph nodes throughout the body. This stage is typically diagnosed through physical exams, blood work, and biopsy or aspirate of swollen nodes.

Colt’s lymph nodes were enlarged, and the diagnosis came quickly. Stage 3 means the cancer isn’t localized anymore; it’s widespread, and that makes treatment urgent.

Early Symptoms and How We Knew Something Was Wrong

The signs were subtle at first: Colt was sleeping more, seemed less interested in walks, and had a reduced appetite. Then I noticed the swollen lymph nodes in his neck and behind his knees.

If you spot any of these symptoms, get to the vet right away:

• Swollen lymph nodes (especially neck, chest, groin)
• Fatigue or lethargy
• Loss of appetite
• Weight loss
• Increased thirst or urination

The Diagnosis Process

Our vet performed a fine needle aspirate and blood tests. Waiting for results was agonizing. When the diagnosis came back as Stage 3 multicentric lymphoma, we were devastated—but also determined to fight.

Treatment Options for Stage 3 Canine Lymphoma

There are several paths, depending on your dog’s age, overall health, and finances:

• CHOP chemotherapy protocol: the gold standard, offering the best chance at remission.
• Single-agent chemo: less expensive, with fewer side effects.
• Prednisone alone: a steroid that can provide temporary relief, but not a cure.

Colt started the CHOP protocol. He handled it like a champ most days, though there were tough ones too.

Life Expectancy and Prognosis

With CHOP chemo, many dogs go into remission for 6 to 12 months. Some live even longer. Without treatment, survival is usually just 1 to 2 months.

Prognosis depends on how your dog responds to treatment, the type of lymphoma, and how early it was caught.

Quality of Life Considerations

We focused on making Colt comfortable. That meant:

• Feeding him his favorite foods
• Giving extra cuddles and quiet time
• Tracking his energy levels and symptoms
• Letting him call the shots on walks, playtime, and naps

Every good day became a gift. And even the hard days were filled with love.

When It’s Time to Say Goodbye

The worst part of this journey was knowing we might lose him. Eventually, Colt began to decline. His appetite faded, his breathing changed, and he no longer wanted to go outside.

We chose to say goodbye at home, with a vet who helped him pass peacefully, surrounded by love. It was the hardest choice—and the most compassionate one.

Resources and Support for Pet Parents

When you’re navigating the emotional and financial weight of a cancer diagnosis—or coping with the loss of your beloved dog—finding the right support can make all the difference. Below are trusted resources to help you feel less alone during this incredibly hard journey.

Vet-Recommended Books & Websites

• The Dog Cancer Survival Guide by Dr. Demian Dressler & Dr. Susan Ettinger – a compassionate, comprehensive guide to understanding treatment and holistic care.
• Veterinary Partner – reliable medical information straight from veterinary professionals.
• CanineLymphoma.com – created by a pet parent who went through it, offering helpful articles and community insight.

Pet Loss Grief Support Groups

• The Association for Pet Loss and Bereavement (APLB) – offers online chat rooms, support forums, and grief counselors trained in pet loss.
• Lap of Love Grief Support – personalized sessions, support groups, and webinars led by licensed counselors specializing in pet loss.
• Rainbow Bridge Pet Loss Grief Center – a gentle space to honor your pet’s memory with poems, memorials, and coping tools.

Financial Assistance for Treatment

• The Pet Fund – helps cover non-emergency vet care, including cancer treatments.
• RedRover Relief – grants for pet guardians facing financial hardship during a crisis.
• Waggle – a crowdfunding platform dedicated to helping pet owners pay for medical treatments directly to vets.

Pet Cancer Research & Awareness

• Morris Animal Foundation – funds cancer research for companion animals and provides updates on breakthroughs.
• National Canine Cancer Foundation – raises funds for research and shares personal stories from other dog parents.

Final Thoughts

If you’re walking this road right now, know that you’re not alone. Stage 3 lymphoma is brutal, but your dog will still have moments of joy, tail wags, and love. Advocate for them, cherish every snuggle, and take it one day at a time.

Colt taught me how to be strong, how to show up, and how to say goodbye with grace. I carry him with me still, in the quiet morning walks and in the soft thud of paws that I still imagine beside me.

Hug your pup a little tighter today.

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